Hollow carbon nanospheres dotted with Gd–Fe nanoparticles for magnetic resonance and photoacoustic imaging

Hui Zhang; Tianze Wu; Yi Chen; Qianqian Zhang; Zhenxia Chen; Yun Ling; Yu Jia; Yongtai Yang; Xiaofeng Liu; Yaming Zhou

doi:10.1039/D1NR02914B

Hollow carbon nanospheres dotted with Gd–Fe nanoparticles for magnetic resonance and photoacoustic imaging†

Hui Zhang,^a Tianze Wu,^a Yi Chen,^a Qianqian Zhang,^a Zhenxia Chen,

^a Yun Ling,

*^ab Yu Jia,^a Yongtai Yang,^a Xiaofeng Liu^a and Yaming Zhou

*^a

Author affiliations

* Corresponding authors

^a Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, China
E-mail: yunling@fudan.edu.cn, ymzhou@fudan.edu.cn

^b Zhuhai Fudan Innovation Institute, Zhuhai, Guangdong, China

Abstract

Integrating magnetic resonance (MR) and photoacoustic (PA) contrast agents into porous nanomaterials is a favorable way for screening of potential theranostic nanomedicines. Hollow carbon nanospheres (HCSs) dotted with GdPO₄ and γ-Fe₂O₃ (Gd–Fe) nanoparticles are therefore prepared and studied in this work. The resultant Gd–Fe/HCSs possess a size of ∼100 nm with a cavity of ∼80 nm and a shell thickness of ∼10 nm, where the magnetic Gd–Fe nanoparticles are dotted. Owing to the synergistic effects, the Gd–Fe/HCSs give 2.5 times enhanced PA signals as compared with HCSs as well as the inherited MR imaging properties from Gd–Fe nanoparticles. In vivo MR and PA imaging of the liver in mice are consequently evaluated and validated. Furthermore, taking the tunable particle size, hollow cavity, shell thickness, and dotted amounts of nanoparticles into consideration, our studies here provide a useful structural model for the synergistic integration of MR and PA imaging in HCSs.

This article is part of the themed collection: Nanoscale and Nanoscale Horizons: Carbon-based nanomaterials

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Hollow carbon nanospheres dotted with Gd–Fe nanoparticles for magnetic resonance and photoacoustic imaging†

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Hollow carbon nanospheres dotted with Gd–Fe nanoparticles for magnetic resonance and photoacoustic imaging

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