Two-dimensional intermetallic PtBi/Pt core/shell nanoplates overcome tumor hypoxia for enhanced cancer therapy

Yongchun Liu; Xinhao Li; Yu Shi; Youjuan Wang; Xiaojing Zhao; Xiangyang Gong; Ren Cai; Guosheng Song; Mei Chen; Xiaobing Zhang

doi:10.1039/D1NR02561A

Two-dimensional intermetallic PtBi/Pt core/shell nanoplates overcome tumor hypoxia for enhanced cancer therapy†

Yongchun Liu,‡^a Xinhao Li,‡^a Yu Shi,^a Youjuan Wang,^b Xiaojing Zhao,^c Xiangyang Gong,^b Ren Cai,

^a Guosheng Song,

^b Mei Chen

*^a and Xiaobing Zhang

^b

Author affiliations

* Corresponding authors

^a College of Materials Science and Engineering, Hunan University, Changsha 410082, China
E-mail: chenmei@hnu.edu.cn

^b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China

^c College of Chemistry and Materials, Quanzhou Normal University, Quanzhou 362000, China

Abstract

The design of multifunctional nanoplatforms is of great importance for improving hypoxia-induced therapeutic outcomes, especially for overcoming radiotherapy (RT) tolerance. Here, two-dimensional intermetallic PtBi/Pt nanoplates (PtBi NPs) were designed as a therapeutic platform to in situ generate oxygen, and thereby overcome tumor hypoxia for boosting photothermal/radiotherapy (PTT/RT). With high X-ray attenuation coefficient, PtBi NPs exhibited outstanding radiotherapy sensitization characteristics. Moreover, the high photothermal effect of PtBi NPs could promote the catalytic activity of PtBi NPs to achieve a synergistic PTT/RT effect. PEGylated PtBi NPs (PtBi-PEG) exhibited excellent biocompatibility, prolonged blood circulation time and enhanced tumor accumulation. Finally, PtBi-PEG showed excellent trimodal contrast enhancement for infrared (IR) imaging, photoacoustic (PA) imaging and X-ray imaging, facilitating imaging-guided cancer therapy. Thus, our work highlights PtBi-PEG as a novel multifunctional theranostic nanoplatform with great potential for future multimodal imaging-guided synergistic cancer therapy.

Nanoscale

Two-dimensional intermetallic PtBi/Pt core/shell nanoplates overcome tumor hypoxia for enhanced cancer therapy†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Two-dimensional intermetallic PtBi/Pt core/shell nanoplates overcome tumor hypoxia for enhanced cancer therapy

Social activity

Search articles by author

Spotlight

Advertisements