Issue 5, 2021
From the journal:

RSC Medicinal Chemistry

Cucurbit[8]uril-based supramolecular hydrogels for biomedical applications

Zeyu Wang,†a   Mingju Shui,†a   Ian W. Wyman,b   Qing-Wen Zhang*a  and  Ruibing Wang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
E-mail: qwzhang@um.edu.mo, rwang@um.edu.mo

b Department of Chemistry, Queen's University, Kingston, ON, Canada

Abstract

As a member of the cucurbit[n]uril family (where n denotes the number of glycoluril units), cucurbit[8]uril (CB[8]) possesses a large cavity volume and is able to accommodate two guests simultaneously. Therefore, CB[8] has been adapted as a dynamic noncovalent crosslinker to form various supramolecular hydrogels. These CB[8]-based hydrogels have been investigated for various biomedical applications due to their good biocompatibility and dynamic properties afforded by host–guest interactions. In this review, we summarize the hydrogels that have been dynamically fabricated via supramolecular crosslinking of polymers by CB[8] reported during the past decade, and discuss their design principles, innovative applications in biomedical science and their future prospects.

Graphical abstract: Cucurbit[8]uril-based supramolecular hydrogels for biomedical applications

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/D1MD00019E
Article type
Review Article
Submitted
21 Jan 2021
Accepted
01 Mar 2021
First published
10 Mar 2021

RSC Med. Chem., 2021,12, 722-729

Permissions

Request permissions

Cucurbit[8]uril-based supramolecular hydrogels for biomedical applications

Z. Wang, M. Shui, I. W. Wyman, Q. Zhang and R. Wang, RSC Med. Chem., 2021, 12, 722 DOI: 10.1039/D1MD00019E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements