Issue 9, 2021

Electro-oxidative C–H azolation of quinoxalin-2(1H)-ones

Abstract

We have developed a practical, general protocol for direct C–H azolation reactions of quinoxalin-2(1H)-ones by electro-oxidative cross-coupling. These mild reactions proceed under metal-, oxidant-, and reagent-free conditions to provide synthetically useful azolated quinoxalin-2(1H)-ones. Furthermore, the reactions can be carried out with a pencil lead as an electrode and a 3 V battery as a power source, revealing the remarkable flexibility of this protocol.

Graphical abstract: Electro-oxidative C–H azolation of quinoxalin-2(1H)-ones

Supplementary files

Article information

Article type
Communication
Submitted
09 Mar 2021
Accepted
13 Apr 2021
First published
14 Apr 2021

Green Chem., 2021,23, 3246-3249

Electro-oxidative C–H azolation of quinoxalin-2(1H)-ones

K. Niu, L. Ding, P. Zhou, Y. Hao, Y. Liu, H. Song and Q. Wang, Green Chem., 2021, 23, 3246 DOI: 10.1039/D1GC00861G

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