Issue 18, 2021
From the journal:

Food & Function

Probiotic yeast BR14 ameliorates DSS-induced colitis by restoring the gut barrier and adjusting the intestinal microbiota†

Zhiyong Mu,‡a   Yijin Yang,‡ab   Yongjun Xia, ORCID logo a   Fukang Wang,a   Yiwei Sun,a   Ying Yangc  and  Lianzhong Ai ORCID logo *a  

* Corresponding authors

a Shanghai Engineering Research Center of Food Microbiology, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, PR China
E-mail: ailianzhong1@126.com
Fax: +86-21-55897302
Tel: +86-21-55897302

b School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai, PR China

c Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, PR China

Abstract

The probiotic Saccharomyces boulardii has been widely used in colitis treatment; however, the beneficial effects of other yeast species are rarely studied. Saccharomyces cerevisiae with great stress tolerance and potential in colitis treatment was investigated in this study. Among 16 yeast strains, BR14, BR54, and BR174 strains showed good stress-resistant capacity, anti-inflammatory activity, and little toxicity to macrophages. As for the colitis mice, BR14 inhibited weight loss the most, as well as the disease activity index and colon shortening. After treatment with BR14, the expression levels of genes related to histological damage were all upregulated. BR14 significantly attenuated the expression levels of TNF-α and IL-6, while the expression of IL-10 was upregulated. Additionally, BR14 rebalanced the intestinal microbial composition of colitis mice by increasing the abundance of Muribaculaceae, Lactobacillus and Rikenellaceae and decreasing the abundance of Turicibacter, Escherichia-Shigella, Desulfovibrio, and Lachnospiraceae. In summary, BR14 exhibited great potential in alleviating colitis through restoring the gut barrier and adjusting the intestinal microbiota.

Graphical abstract: Probiotic yeast BR14 ameliorates DSS-induced colitis by restoring the gut barrier and adjusting the intestinal microbiota

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Article information

DOI
https://doi.org/10.1039/D1FO01314A
Article type
Paper
Submitted
27 Apr 2021
Accepted
18 Jul 2021
First published
22 Jul 2021

Food Funct., 2021,12, 8386-8398

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Probiotic yeast BR14 ameliorates DSS-induced colitis by restoring the gut barrier and adjusting the intestinal microbiota

Z. Mu, Y. Yang, Y. Xia, F. Wang, Y. Sun, Y. Yang and L. Ai, Food Funct., 2021, 12, 8386 DOI: 10.1039/D1FO01314A

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