Issue 29, 2021

Layered terbium hydroxides for simultaneous drug delivery and imaging

Abstract

Layered rare-earth hydroxides have begun to gather increasing attention as potential theranostic platforms owing to their extensive intercalation chemistry combined with magnetic and fluorescent properties. In this work, the potential of layered terbium hydroxide (LTbH) as a platform for simultaneous drug delivery and fluorescence imaging was evaluated. LTbH-Cl ([Tb2(OH)5]Cl·yH2O) was loaded with three nonsteroidal anti-inflammatory drugs (diclofenac, ibuprofen, and naproxen) via ion-exchange. Drug release studies in phosphate buffered saline (pH = 7.4) revealed all three formulations release their drug cargo rapidly over the course of approximately 5 hours. In addition, solid state fluorescence studies indicated that fluorescence intensity is strongly dependent on the identity of the guest anion. It was postulated that this feature may be used to track the extent of drug release from the formulation, which was subsequently successfully demonstrated for the ibuprofen loaded LTbH. Overall, LTbH exhibits good biocompatibility, high drug loading, and a strong, guest-dependent fluorescence signal, all of which are desirable qualities for theranostic applications.

Graphical abstract: Layered terbium hydroxides for simultaneous drug delivery and imaging

Supplementary files

Article information

Article type
Paper
Submitted
15 Apr 2021
Accepted
06 Jul 2021
First published
06 Jul 2021
This article is Open Access
Creative Commons BY license

Dalton Trans., 2021,50, 10275-10290

Layered terbium hydroxides for simultaneous drug delivery and imaging

M. Strimaite, C. L. G. Harman, H. Duan, Y. Wang, G. Davies and G. R. Williams, Dalton Trans., 2021, 50, 10275 DOI: 10.1039/D1DT01251G

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