Issue 1, 2022
From the journal:

CrystEngComm

Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid†

Magdalena Kaliszczak,a   Pierrick Durand,b   Emmanuel Wenger, ORCID logo b   Manuel Dossot,a   Franca Jones, ORCID logo c   Damien W. M. Arrigan ORCID logo *c  and  Grégoire Herzog ORCID logo *a  

* Corresponding authors

a Chimie Physique et Microbiologie pour l'Environment – LCPME, CNRS – Université de Lorraine, Villers Les Nancy, France
E-mail: gregoire.herzog@univ-lorraine.fr

b CRM2 UMR 7036, Université de Lorraine, Vandoeuvre-lès-Nancy, Lorraine, France

c School of Molecular & Life Sciences, Curtin University, GPO Box U1987, Perth, Western Australia, Australia
E-mail: D.Arrigan@curtin.edu.au

Abstract

Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation was achieved, as verified by X-ray diffraction and Raman spectroscopy. Positive interfacial potentials favoured the formation of one polymorphic form of caffeine:1-hydroxy-2-naphthoic acid cocrystal. This approach to electrochemically controlled cocrystallisation opens up new possibilities for drug development.

Graphical abstract: Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1CE01281A
Article type
Communication
Submitted
23 Sep 2021
Accepted
28 Nov 2021
First published
02 Dec 2021

CrystEngComm, 2022,24, 48-51

Permissions

Request permissions

Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid

M. Kaliszczak, P. Durand, E. Wenger, M. Dossot, F. Jones, D. W. M. Arrigan and G. Herzog, CrystEngComm, 2022, 24, 48 DOI: 10.1039/D1CE01281A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements