Issue 17, 2022
From the journal:

Chemical Communications

Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi†

Anna Koudrina,a   Celine Chartrand,a   Greg O Cron,bcd   Jonathan O’Brien,d   Eve C Tsaibcd  and  Maria C DeRosa ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Carleton University, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada
E-mail: maria.derosa@carleton.ca

b Ottawa Hospital Research Institute, 1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada

c Faculty of Medicine, University of Ottawa, 75 Laurier Ave. E, Ottawa, ON K1N 6N5, Canada

d The Ottawa Hospital, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada

Abstract

Targeting of molecular constituents of thrombi with aptamer functionalized core–shell nanoparticles (CSN) allowed for high resolution clot delineation in T2-weighted magnetic resonance imaging. Meanwhile, the gold-coating demonstrated sufficient contrast capabilities in computed tomography (1697 HU μM−1). This targeted CSN formulation could allow for precise imaging of blood clots at low nanomolar concentrations.

Graphical abstract: Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi

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Article information

DOI
https://doi.org/10.1039/D1CC03817F
Article type
Communication
Submitted
26 Sep 2021
Accepted
23 Jan 2022
First published
24 Jan 2022

Chem. Commun., 2022,58, 2870-2873

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Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi

A. Koudrina, C. Chartrand, G. O. Cron, J. O’Brien, E. C. Tsai and M. C. DeRosa, Chem. Commun., 2022, 58, 2870 DOI: 10.1039/D1CC03817F

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