Issue 46, 2021
From the journal:

Chemical Communications

Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity†

Akinobu Z. Suzuki,‡a   Taichi Sakano,‡a   Hirona Sasaki,a   Rei Watahiki,a   Masaki Sone,a   Kazuki Horikawab  and  Toshiaki Furuta ORCID logo *a  

* Corresponding authors

a Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Japan
E-mail: furuta@biomol.sci.toho-u.ac.jp
Fax: +81 47-472-1169

b Department of Optical Imaging, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Cho, Tokushima City, Tokushima 770-8503, Japan

Abstract

We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds.

Graphical abstract: Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity

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Article information

DOI
https://doi.org/10.1039/D1CC01405F
Article type
Communication
Submitted
15 Mar 2021
Accepted
23 Apr 2021
First published
21 May 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 5630-5633

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Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity

A. Z. Suzuki, T. Sakano, H. Sasaki, R. Watahiki, M. Sone, K. Horikawa and T. Furuta, Chem. Commun., 2021, 57, 5630 DOI: 10.1039/D1CC01405F

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