Issue 36, 2021
From the journal:

Chemical Communications

Umpolung coupling of pyridine-2-carboxaldehydes and propargylic carbonates via N-heterocyclic carbene/palladium synergetic catalysis†

Weiyang Bi,ab   Yunhui Yang,abc   Song Ye ORCID logo ab  and  Congyang Wang ORCID logo *abc  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: wangcy@iccas.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, China

c Physical Science Laboratory, Huairou National Comprehensive Science Center, Beijing 101400, China

Abstract

The umpolung cross-coupling reaction of pyridine-2-carboxaldehydes and propargylic carbonates has been developed for the first time through N-heterocyclic carbene/palladium cooperative catalysis with the judicious selection of the palladium catalyst, ligand and N-heterocyclic carbene, giving the propargylic ketones regioselectively.

Graphical abstract: Umpolung coupling of pyridine-2-carboxaldehydes and propargylic carbonates via N-heterocyclic carbene/palladium synergetic catalysis

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Article information

DOI
https://doi.org/10.1039/D1CC01311D
Article type
Communication
Submitted
10 Mar 2021
Accepted
26 Mar 2021
First published
27 Mar 2021

Chem. Commun., 2021,57, 4452-4455

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Umpolung coupling of pyridine-2-carboxaldehydes and propargylic carbonates via N-heterocyclic carbene/palladium synergetic catalysis

W. Bi, Y. Yang, S. Ye and C. Wang, Chem. Commun., 2021, 57, 4452 DOI: 10.1039/D1CC01311D

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