Issue 29, 2021
From the journal:

Chemical Communications

Low-valent dialkoxytitanium(ii): a useful tool for the synthesis of functionalized seven-membered ring compounds†

Florent Bodinier, ORCID logo a   Youssouf Sanogo,a   Janick Ardisson, ORCID logo a   Marie-Isabelle Lannou ORCID logo a  and  Geoffroy Sorin ORCID logo *a  

* Corresponding authors

a Unité CNRS UMR 8038 Université de Paris, Faculté de Pharmacie, Sorbonne Paris Cité, 4 avenue de l’Observatoire, 75270 Paris Cedex 06, France
E-mail: geoffroy.sorin@u-paris.fr

Abstract

Herein, we describe unprecedented access to all-carbon or heterocyclic seven-membered ring frameworks from 1,8-ene-ynes promoted by inexpensive low-valent titanium(II) species, readily available from Ti(OiPr)4 and Grignard reagent. A broad range of cycloheptane, azepane or oxepane derivatives has been obtained (19 examples) with moderate to good yields and an excellent selectivity (up to 95/5 d.r.).

Graphical abstract: Low-valent dialkoxytitanium(ii): a useful tool for the synthesis of functionalized seven-membered ring compounds

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1CC00081K
Article type
Communication
Submitted
06 Jan 2021
Accepted
02 Mar 2021
First published
04 Mar 2021

Chem. Commun., 2021,57, 3603-3606

Permissions

Request permissions

Low-valent dialkoxytitanium(II): a useful tool for the synthesis of functionalized seven-membered ring compounds

F. Bodinier, Y. Sanogo, J. Ardisson, M. Lannou and G. Sorin, Chem. Commun., 2021, 57, 3603 DOI: 10.1039/D1CC00081K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements