Issue 16, 2021
From the journal:

Biomaterials Science

Targeted delivery of dexamethasone in acute pneumonia†

Qingle Ma,‡a   Chenlu Yao,‡a   Haoliang Shi,‡a   Jialu Xu,a   Huaxing Dai,a   Ziying Fei,a   Yi Wu,b   Ting Lu*b  and  Chao Wang ORCID logo *a  

* Corresponding authors

a Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China
E-mail: cwang@suda.edu.cn

b Department of Biochemistry and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu 215123, China
E-mail: luting@suda.edu.cn

Abstract

Pneumonia has contributed to significant mortality owing to the irreversible injury to the lungs and severe inflammation of the tissue. Dexamethasone (DEX) is regarded as an effective drug to relieve the level of pneumonia, while the adverse effect of which is non-negligible. Here, we developed a targeted delivery strategy based on platelet-derived extracellular vesicles (PEVs), which are naturally occurring nanoparticles released by platelets, for DEX delivery in acute pneumonia, aiming to reduce the side effects and improve the therapeutic efficacy. Our strategy may shed light on the problems in DEX-based acute pneumonia therapy clinically.

Graphical abstract: Targeted delivery of dexamethasone in acute pneumonia

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Article information

DOI
https://doi.org/10.1039/D1BM00924A
Article type
Paper
Submitted
12 Jun 2021
Accepted
16 Jun 2021
First published
09 Jul 2021

Biomater. Sci., 2021,9, 5569-5576

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Targeted delivery of dexamethasone in acute pneumonia

Q. Ma, C. Yao, H. Shi, J. Xu, H. Dai, Z. Fei, Y. Wu, T. Lu and C. Wang, Biomater. Sci., 2021, 9, 5569 DOI: 10.1039/D1BM00924A

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