Optimal fluorescence and photosensitivity properties of dual-functional NaYb1−xF4:Tmx3+ nanoparticles for applications in imaging guided photodynamic therapy

Zhang Jiayin; Wang Qiyu; Liang Hong; Song Guoli; Zhang Zhiguo

doi:10.1039/D0RA09544C

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Optimal fluorescence and photosensitivity properties of dual-functional NaYb_1−xF₄:Tm_x³⁺ nanoparticles for applications in imaging guided photodynamic therapy†

Zhang Jiayin,

^a Wang Qiyu,*^b Liang Hong,^a Song Guoli*^a and Zhang Zhiguo

*^c

Author affiliations

* Corresponding authors

^a School of Technology, Harbin University, Harbin 150086, China
E-mail: SONGGL@aliyun.com

^b School of Physics & Electronic Engineering, Harbin Normal University, Harbin 150025, China
E-mail: hsdwqy@126.com

^c School of Instrumentation Science and Engineering, Harbin Institute of Technology, Harbin 150080, P. R. China
E-mail: zhangzhiguo@hit.edu.cn

Abstract

The fluorescence and photosensitivity properties of NaYb_1−xF₄:Tm_x³⁺ nanoparticles were optimized to develop noninvasive near-infrared fluorescence imaging-guided photodynamic therapy. The emission at 800 nm from Tm³⁺ presented an exponential increase with an increase in the Tm³⁺ doping concentration from 0 to 2%. The photosensitivity properties of NaYb_1−xF₄:Tm_x³⁺ nanoparticles were also studied via the chemoprobe method, which used a reactive oxygen quencher, 1,3-diphenylisobenzofuran (DPBF). With the increase in the doping concentration of Tm³⁺, the generation rate of reactive oxygen species in NaYb_1−xF₄:Tm_x³⁺ nanoparticles decreased linearly at a rate of 0.3. The doping concentration of Tm³⁺ had two opposite effects on the 800 nm emission and generation rates of reactive oxygen species. The competitive relationship was discussed and an optimal value for the Tm³⁺ doping concentration of approximately 1% was determined. At this concentration, the energy of the Yb³⁺ excited state can be fully utilized, and the fluorescence and photosensitivity properties are an effective combination.

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Article information

DOI: https://doi.org/10.1039/D0RA09544C
Article type: Paper
Submitted: 10 Nov 2020
Accepted: 20 Dec 2020
First published: 04 Jan 2021
This article is Open Access

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RSC Adv., 2021,11, 1282-1286

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Optimal fluorescence and photosensitivity properties of dual-functional NaYb_1−xF₄:Tm_x³⁺ nanoparticles for applications in imaging guided photodynamic therapy

Z. Jiayin, W. Qiyu, L. Hong, S. Guoli and Z. Zhiguo, RSC Adv., 2021, 11, 1282 DOI: 10.1039/D0RA09544C

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