Study towards improving artemisinin-based combination therapies

Hai-Ning Lyu; Nan Ma; Yuqing Meng; Xing Zhang; Yin-Kwan Wong; Chengchao Xu; Fulong Liao; Tingliang Jiang; Youyou Tu; Jigang Wang

doi:10.1039/D0NP00079E

Study towards improving artemisinin-based combination therapies

Hai-Ning Lyu,

†^a Nan Ma,

†^a Yuqing Meng,†^a Xing Zhang,^a Yin-Kwan Wong,^a Chengchao Xu,*^af Fulong Liao,^a Tingliang Jiang,^a Youyou Tu

*^a and Jigang Wang*^abcdef

Author affiliations

* Corresponding authors

^a Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
E-mail: ccxu@icmm.ac.cn, yytu@icmm.ac.cn, jgwang@icmm.ac.cn

^b Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

^c Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning 530021, China

^d Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China

^e Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China

^f The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, China

Abstract

Covering: Up to 2020

Artemisinin has made a significant contribution towards global malaria control since its initial discovery. Countless lives have been saved by this unique and miraculous molecule. In 2006, artemisinin-based combination therapies (ACTs) were recommended by the World Health Organization (WHO) as the first-line treatment for uncomplicated malaria infection and have since remained as the mainstays of the antimalarial treatment. Even so, substantial efforts to pursue better curative effects for the treatment of malaria have never ceased, particularly with regards to the circumstances surrounding the appearance of delayed clearance of malaria parasites by 3 day ACT treatments in South-East Asian countries. Strategies to further optimize artemisinin-based therapies, including synthesizing better artemisinin derivatives, developing advanced drug delivery systems, and diversifying artemisinin partner drugs, have been proposed over the past few years. Here, we provide an updated account of the continuous efforts in improving ACTs for better efficacy in curing malarial infection.

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Study towards improving artemisinin-based combination therapies

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