Issue 22, 2020

One-pot synthesis of pyrrolidones from levulinic acid and amines/nitroarenes/nitriles over the Ir-PVP catalyst

Abstract

The synthesis of pyrrolidones via reductive amination of levulinic acid with aniline was examined over polypyrrolidone-stabilized metal nanoparticle catalysts. Among them, Ir metal was the most effective and applicable for the reductive amination of levulinic acid with nitroarenes/nitriles. Importantly, this catalyst was used for the one-pot synthesis of the anti-inflammatory drug indoprofen from 2-formylbenzoic acid and 2-(4-nitrophenyl)propanoic acid.

Graphical abstract: One-pot synthesis of pyrrolidones from levulinic acid and amines/nitroarenes/nitriles over the Ir-PVP catalyst

Supplementary files

Article information

Article type
Communication
Submitted
21 May 2020
Accepted
10 Aug 2020
First published
28 Aug 2020

Green Chem., 2020,22, 7760-7764

Author version available

One-pot synthesis of pyrrolidones from levulinic acid and amines/nitroarenes/nitriles over the Ir-PVP catalyst

C. Chaudhari, M. Shiraishi, Y. Nishida, K. Sato and K. Nagaoka, Green Chem., 2020, 22, 7760 DOI: 10.1039/D0GC01725F

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