Issue 5, 2021
From the journal:

Food & Function

Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice

Ximiao Chen,abc   Chongan Huang,acd   Haiqiu Sun,e   Haofeng Hong,ad   Jie Jin,acd   Chaoyong Bei,*b   Zhongqiu Lu*f  and  Xiaolei Zhang ORCID logo *acdg  

* Corresponding authors

a Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
E-mail: zhangxiaolei@wmu.edu.cn

b Department of Orthopaedics, Affiliated Hospital of Guilin Medical College, Guilin, Guangxi Province, China
E-mail: beichaoyong@glmc.edu.cn

c Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang Province, China

d The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China

e Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China

f Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
E-mail: lzq_640815@163.com

g Chinese Orthopaedic Regenerative Medicine Society, Hangzhou, Zhejiang Province, China

Abstract

Osteoarthritis (OA) is the most common degenerative joint disorder with no effective drugs. Puerarin is a dietary supplement that has wide-ranging pharmacological effects. This study aimed to investigate the effects of Puerarin on OA. The effects of Puerarin on apoptosis, extracellular matrix (ECM) metabolism, and inflammation-related factors were assessed; also, the nuclear factor-κB (NF-κB) signaling pathway and Nrf2/HO-1 (nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1) axis were evaluated to elucidate the working mechanism of Puerarin. Mice were fed with Puerarin to evaluate the therapeutic effect of Puerarin on Osteoarthritis in vivo. The results showed that Puerarin suppressed inflammatory mediators and apoptosis induced by IL-1β treatment in chondrocytes, it may also suppress ECM degradation in IL-1β treated chondrocytes. The mechanism study revealed that Nrf2/HO-1 pathway is involved in Puerarin induced inhibition of NF-κB signaling pathway. Finally, in vivo study demonstrated that Puerarin could postpone the progression of OA in mice and relieve the symptoms of pain. In conclusion, Puerarin may potentially alleviate OA progression, and the mechanism may relate to the Nrf2/HO-1 pathway regulation.

Graphical abstract: Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice

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Article information

DOI
https://doi.org/10.1039/D0FO03076G
Article type
Paper
Submitted
23 Nov 2020
Accepted
31 Jan 2021
First published
05 Feb 2021

Food Funct., 2021,12, 2075-2089

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Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice

X. Chen, C. Huang, H. Sun, H. Hong, J. Jin, C. Bei, Z. Lu and X. Zhang, Food Funct., 2021, 12, 2075 DOI: 10.1039/D0FO03076G

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