Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover via regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice

Meng Fu; Yingying Tian; Tianqi Zhang; Qiping Zhan; Lei Zhang; Jingfeng Wang

doi:10.1039/D0FO01563F

Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover via regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice

Meng Fu,

†^a Yingying Tian,†^ab Tianqi Zhang,^a Qiping Zhan,

^a Lei Zhang^a and Jingfeng Wang*^a

Author affiliations

* Corresponding authors

^a College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, China
E-mail: jfwang@ouc.edu.cn
Tel: +86 0532 82031948

^b Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong Province 266071, China

Abstract

Here, we compared the effects of marine DHA-enriched phosphatidylcholine (DHA-PC) and EPA-enriched phosphatidylcholine (EPA-PC) on high bone turnover in a model of osteoporosis induced by bilateral ovariectomy in vivo, and further investigated the possible protective mechanisms. Meanwhile, DHA-PC and EPA-PC clearly ameliorated the microstructure of the trabecular bone and accelerated bone mineral apposition rate, additionally increasing bone mineral density and biomechanical properties of the bone. Furthermore, gene and protein expression levels suggest that DHA-PC and EPA-PC inhibited overactive osteogenesis via down-regulation of the expression of the osteogenesis-related Wnt/β-catenin signaling pathway. In conclusion, DHA-PC and EPA-PC reduced excessive osteogenesis via normalization of Wnt/β-catenin expression. These results may contribute to the elucidation of the anti-osteoporotic properties of DHA-PC and EPA-PC and further develop their potential application value as a functional food.

Article information

https://doi.org/10.1039/D0FO01563F

Article type

Paper

Submitted

16 Jun 2020

Accepted

28 Sep 2020

First published

19 Oct 2020

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Food Funct., 2020,11, 10094-10104

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Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover via regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice

M. Fu, Y. Tian, T. Zhang, Q. Zhan, L. Zhang and J. Wang, Food Funct., 2020, 11, 10094 DOI: 10.1039/D0FO01563F

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Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover via regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice

Abstract

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Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover via regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice

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