Issue 16, 2020

Iridium-catalyzed enantioselective reductive amination of aromatic ketones

Abstract

A highly efficient direct asymmetric reductive amination of aromatic ketones catalyzed by an iridium complex of Josiphos-type binaphane ligands was described. This concise and practical method provided chiral amines in high yields and enantioselectivities (up to 99% ee).

Graphical abstract: Iridium-catalyzed enantioselective reductive amination of aromatic ketones

Supplementary files

Article information

Article type
Communication
Submitted
25 Jun 2020
Accepted
15 Jul 2020
First published
15 Jul 2020

Catal. Sci. Technol., 2020,10, 5448-5452

Iridium-catalyzed enantioselective reductive amination of aromatic ketones

R. Liu, B. Li, J. Han, D. Zhang, M. Li, L. Yao, W. Zhao, Q. Wang, R. Jiang and H. Nie, Catal. Sci. Technol., 2020, 10, 5448 DOI: 10.1039/D0CY01271H

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