Inhibition of immunosuppressive indoleamine 2,3-dioxygenase by targeting the heme and apo-form

Nirmalya Pradhan; Nasim Akhtar; Barnali Nath; Jorge Peña-García; Anjali Gupta; Horacio Pérez-Sánchez; Sachin Kumar; Debasis Manna

doi:10.1039/D0CC06942F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Inhibition of immunosuppressive indoleamine 2,3-dioxygenase by targeting the heme and apo-form†

Nirmalya Pradhan,‡^a Nasim Akhtar,‡^a Barnali Nath,^b Jorge Peña-García,^c Anjali Gupta,^b Horacio Pérez-Sánchez,

^c Sachin Kumar

^b and Debasis Manna

*^a

Author affiliations

* Corresponding authors

^a Indian Institute of Technology Guwahati, Chemistry, Guwahati, Assam, India
E-mail: dmanna@iitg.ac.in

^b Indian Institute of Technology Guwahati, Biosciences and Bioengineering, Guwahati, Assam, India

^c Universidad Católica de Murcia, Computer Engineering Department, Guadalupe-30107, Spain

Abstract

Inhibition of immunomodulating enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is considered one of the potential approaches in the fight against cancer and other diseases. Comprehensive biophysical and cellular studies have shown that quinine derivatives effectively inhibit the activity of IDO1. Mechanistic studies revealed that the potent quinine derivatives compete with heme for binding to apo-IDO1 and perturb its reversible binding propensity to apo-IDO1 via the formation of a heme-inhibitor complex. This IDO1 inhibitory pathway could provide new avenues to immunotherapy-based drug discovery strategies.

Download options Please wait...

Supplementary files

Supplementary information PDF (7900K)

Article information

DOI: https://doi.org/10.1039/D0CC06942F
Article type: Communication
Submitted: 19 Oct 2020
Accepted: 30 Nov 2020
First published: 08 Dec 2020

Download Citation

Chem. Commun., 2021,57, 395-398

Permissions

Request permissions

Inhibition of immunosuppressive indoleamine 2,3-dioxygenase by targeting the heme and apo-form

N. Pradhan, N. Akhtar, B. Nath, J. Peña-García, A. Gupta, H. Pérez-Sánchez, S. Kumar and D. Manna, Chem. Commun., 2021, 57, 395 DOI: 10.1039/D0CC06942F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Inhibition of immunosuppressive indoleamine 2,3-dioxygenase by targeting the heme and apo-form†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Inhibition of immunosuppressive indoleamine 2,3-dioxygenase by targeting the heme and apo-form

Social activity

Search articles by author

Spotlight

Advertisements