Issue 86, 2020

Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization of norbornene and norbornadiene

Abstract

A highly enantioselective Pd/Xiang-Phos-catalyzed carbohetero-functionalization of norbornene is described, giving a direct access to various chiral norbornane-fused dihydrofurans and dihydro-pyrroles. This synthetic methodology provides the first example of asymmetric carboetherification of norbornene, and also tolerates norbornadiene well.

Graphical abstract: Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization of norbornene and norbornadiene

Supplementary files

Article information

Article type
Communication
Submitted
21 Jul 2020
Accepted
15 Sep 2020
First published
18 Sep 2020

Chem. Commun., 2020,56, 13125-13128

Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization of norbornene and norbornadiene

M. Tao, W. Li and J. Zhang, Chem. Commun., 2020, 56, 13125 DOI: 10.1039/D0CC04996D

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