Access to dihydropyrano[3,2-b]pyrrol-5-ones skeletons by N-heterocyclic carbene-catalyzed [3+3] annulations†
Jing
Qi 
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Abstract
A novel and efficient NHC-catalyzed [3+3] annulation of enals with pyrrol-4-ones was developed, thus providing the dihydropyrano[3,2-b]pyrrol-5-one core structures with broad scope and good to excellent enantioselectivities. Notably, this strategy could also expand to the synthesis of axially chiral compounds and polysubstituted indoles.
![Graphical abstract: Access to dihydropyrano[3,2-b]pyrrol-5-ones skeletons by N-heterocyclic carbene-catalyzed [3+3] annulations](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D0CC04661B&imageInfo.ImageIdentifier.Year=2020)
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