Issue 68, 2020
From the journal:

Chemical Communications

Copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes: synthesis of fully substituted indoles†

Yang Yu,a   Xin-Yu Wang,a   Ju-Yin Peng,a   Tao Liua  and  Yu-Long Zhao ORCID logo *a  

* Corresponding authors

a Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China
E-mail: zhaoyl351@nenu.edu.cn

Abstract

A novel copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes has been developed for the first time. This reaction provides a new and highly efficient method for the synthesis of fully substituted indoles by formation of four new bonds and two rings from readily available starting materials in a single step.

Graphical abstract: Copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes: synthesis of fully substituted indoles

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Article information

DOI
https://doi.org/10.1039/D0CC00512F
Article type
Communication
Submitted
19 Jan 2020
Accepted
20 Jul 2020
First published
22 Jul 2020

Chem. Commun., 2020,56, 9815-9818

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Copper-catalyzed cascade cyclization reaction of 3-aminocyclobutenones with electron-deficient internal alkynes: synthesis of fully substituted indoles

Y. Yu, X. Wang, J. Peng, T. Liu and Y. Zhao, Chem. Commun., 2020, 56, 9815 DOI: 10.1039/D0CC00512F

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