Single-atom nanozymes for biological applications

Jiahui Pei; Ruoli Zhao; Xiaoyu Mu; Junying Wang; Changlong Liu; Xiao-Dong Zhang

doi:10.1039/D0BM01447H

Single-atom nanozymes for biological applications

Jiahui Pei,†^a Ruoli Zhao,†^a Xiaoyu Mu,†^ab Junying Wang,^a Changlong Liu*^a and Xiao-Dong Zhang

*^ab

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* Corresponding authors

^a Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China
E-mail: xiaodongzhang@tju.edu.cn, liuchanglong@tju.edu.cn

^b Tianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China

Abstract

Nanozymes have been widely used as highly active and stable arterial enzymes due to their controllable electronic transfer and unique catalytic reaction route. However, the development of nanozymes is hindered by their ambiguous structure, insufficient activity and inadequate substrate selectivity. In comparison, single-atom nanozymes (SAzymes) hold superior catalytic activity 10–100 times higher than conventional nanozymes by maximizing the utilization of metal atom dispersion, and exhibit versatile catalytic selectivity through precisely adjusting the atom spatial configuration. In this review, we highlight several well-defined SAzymes, and discuss their accurate atom configuration, catalytic mechanisms, enzyme-like activity, and applications in cancer treatment, brain disease, and wound healing. It is of great significance to understand the advantages and properties of SAzymes for further medical development.

Article information

https://doi.org/10.1039/D0BM01447H

Article type

Review Article

Submitted

27 Aug 2020

Accepted

29 Sep 2020

First published

01 Oct 2020

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Biomater. Sci., 2020,8, 6428-6441

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Single-atom nanozymes for biological applications

J. Pei, R. Zhao, X. Mu, J. Wang, C. Liu and X. Zhang, Biomater. Sci., 2020, 8, 6428 DOI: 10.1039/D0BM01447H

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Biomaterials Science

Single-atom nanozymes for biological applications

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Single-atom nanozymes for biological applications

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