Issue 18, 2020

In vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flow

Abstract

The flow behavior of blood is determined mainly by red blood cell (RBC) deformation and aggregation as well as blood viscoelasticity. These intricately interdependent parameters should be monitored by healthcare providers to understand all aspects of circulatory flow dynamics under numerous cases including cardiovascular and infectious diseases. Current medical instruments and microfluidic systems lack the ability to quantify these parameters all at once and in physiologically relevant flow conditions. This work presents a handheld platform and a measurement method for quantitative analysis of multiple of these parameters from 50 μl undiluted blood inside a miniaturized channel. The assay is based on an optical transmission analysis of collective RBC deformation and aggregation under near-infrared illumination during a 1 s damped oscillatory flow and at stasis, respectively. Measurements with blood of different hemo-rheological properties demonstrate that the presented approach holds a potential for initiating simultaneous and routine on-chip blood flow analysis even in resource-poor settings.

Graphical abstract: In vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flow

Supplementary files

Article information

Article type
Paper
Submitted
27 Mar 2020
Accepted
11 Jun 2020
First published
06 Jul 2020

Analyst, 2020,145, 5996-6005

In vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flow

Z. Isiksacan, M. Serhatlioglu and C. Elbuken, Analyst, 2020, 145, 5996 DOI: 10.1039/D0AN00604A

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