Non-cytotoxic, temperature-responsive and antibacterial POEGMA based nanocomposite coatings with silver nanoparticles

Svyatoslav Nastyshyn; Joanna Raczkowska; Yurij Stetsyshyn; Barbara Orzechowska; Andrzej Bernasik; Yana Shymborska; Monika Brzychczy-Włoch; Tomasz Gosiewski; Ostap Lishchynskyi; Halyna Ohar; Dorota Ochońska; Kamil Awsiuk; Andrzej Budkowski

doi:10.1039/C9RA10874B

Non-cytotoxic, temperature-responsive and antibacterial POEGMA based nanocomposite coatings with silver nanoparticles†

Svyatoslav Nastyshyn,^a Joanna Raczkowska,*^a Yurij Stetsyshyn,

*^b Barbara Orzechowska,^c Andrzej Bernasik,

^d Yana Shymborska,^b Monika Brzychczy-Włoch,^e Tomasz Gosiewski,^e Ostap Lishchynskyi,^b Halyna Ohar,^b Dorota Ochońska,^e Kamil Awsiuk^a and Andrzej Budkowski^a

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* Corresponding authors

^a Smoluchowski Institute of Physics, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland
E-mail: joanna.raczkowska@uj.edu.pl

^b Lviv Polytechnic National University, St. George's Square 2, 79013 Lviv, Ukraine
E-mail: yrstecushun@ukr.net

^c Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, 31-342 Kraków, Poland

^d Faculty of Physics and Applied Computer Science, Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, Al. Mickiewicza 30, 30-049 Kraków, Poland

^e Chair of Microbiology, Department of Molecular Medical Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Czysta 18, 31-121 Kraków, Poland

Abstract

Non-cytotoxic, temperature-responsive and antibacterial poly(di(ethylene glycol)methyl ether methacrylate) – POEGMA188 based nanocomposite coatings attached to a glass surface were successfully prepared using ATRP polymerization. The thickness, morphology and wettability of the resulting coatings were analyzed using ellipsometry, AFM and contact angle measurements, respectively. The strong impact of the thicknesses of the POEGMA188 grafted brush coatings and content of AgNPs on the morphology and temperature-induced wettability changes of the nanocomposite was demonstrated. In addition to the strong temperature-dependent antibacterial activity, the proposed nanocomposite coatings have no significant cytotoxic effect towards normal cells. Moreover, the slight anti-cancer effect of AgNPs may be suggested.

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Non-cytotoxic, temperature-responsive and antibacterial POEGMA based nanocomposite coatings with silver nanoparticles†

Abstract

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Non-cytotoxic, temperature-responsive and antibacterial POEGMA based nanocomposite coatings with silver nanoparticles

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