Issue 32, 2019
From the journal:

Organic & Biomolecular Chemistry

An efficient synthesis of oxazolines via a cascade reaction between azaoxyallyl cations and 1,2-benzisoxazoles†

Li Sun,‡a   Yi Liu,‡a   Yankai Wang,a   Yuanyuan Li,a   Zhiwen Liu,a   Tao Lua  and  Wenhai Li ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing, P. R. China
E-mail: liwenghai@cpu.edu.cn

Abstract

A formal [3 + 2] cycloaddition reaction between the C and O terminals of azaoxyallyl cations formed in situ and 1,2-benzisoxazoles has been realized. This one-pot cycloaddition method provided an effective and practical pathway to synthesize oxazoline in good yields under mild conditions. The title products exhibited unique fluorescence properties.

Graphical abstract: An efficient synthesis of oxazolines via a cascade reaction between azaoxyallyl cations and 1,2-benzisoxazoles

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Article information

DOI
https://doi.org/10.1039/C9OB01366K
Article type
Paper
Submitted
17 Jun 2019
Accepted
26 Jul 2019
First published
26 Jul 2019

Org. Biomol. Chem., 2019,17, 7526-7530

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An efficient synthesis of oxazolines via a cascade reaction between azaoxyallyl cations and 1,2-benzisoxazoles

L. Sun, Y. Liu, Y. Wang, Y. Li, Z. Liu, T. Lu and W. Li, Org. Biomol. Chem., 2019, 17, 7526 DOI: 10.1039/C9OB01366K

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