Issue 7, 2019
From the journal:

Food & Function

The protective effect of protopanaxatriol-type saponin on intestinal health in antibiotic-treated mice

Minxia Zhang,abc   Jiaqi Zhao,d   Jianjun Deng,abc   Zhiguang Duan,abc   Chenhui Zhu ORCID logo *abc  and  Daidi Fan ORCID logo *abc  

* Corresponding authors

a Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, China
E-mail: zch2005@nwu.edu.cn, fandaidi@nwu.edu.cn
Fax: +86-29-88322585
Tel: +86-29-8830-5118

b Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China

c Biotech. & Biomed. Research Institute, Northwest University, 229 North Taibai Road, Xi'an 710069, China

d School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China

Abstract

Protopanaxatriol saponin (PPT) has excellent anti-cancer, anti-diabetes, and anti-anemia effects, but its effect on intestinal bacteria has rarely been studied. In this study, we investigated whether PPT has the ability to improve intestinal health in antibiotic-treated mice. Model mice were constructed using a broad-spectrum antibiotic, cephalosporin. The composition of the gut microbiota and relative concentration of short-chain fatty acids (SCFAs), short-chain fatty acid receptor proteins (GPR41, GPR43 and GPR109A), tight junction components (ZO-1 and occludin) and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, IL-22 and IFN-γ) were determined. The results showed that PPT improved the composition of the gut microbiota, increased the concentration of SCFAs as well as receptor proteins and tight junction proteins, and decreased the pro-inflammatory cytokines. These findings indicate that PPT has a protective effect on intestinal microbes and enhances the integrity of the intestinal barrier as well as alleviates colonic inflammation in antibiotic-treated mice.

Graphical abstract: The protective effect of protopanaxatriol-type saponin on intestinal health in antibiotic-treated mice

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Article information

DOI
https://doi.org/10.1039/C9FO00242A
Article type
Paper
Submitted
05 Feb 2019
Accepted
05 Jun 2019
First published
06 Jun 2019

Food Funct., 2019,10, 4124-4133

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The protective effect of protopanaxatriol-type saponin on intestinal health in antibiotic-treated mice

M. Zhang, J. Zhao, J. Deng, Z. Duan, C. Zhu and D. Fan, Food Funct., 2019, 10, 4124 DOI: 10.1039/C9FO00242A

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