A visible-light photoactivatable di-nuclear PtIV triazolato azido complex

Kezi Yao; Arnau Bertran; Alison Howarth; Jose M. Goicoechea; Samuel M. Hare; Nicholas H. Rees; Mohammadali Foroozandeh; Alice M. Bowen; Nicola J. Farrer

doi:10.1039/C9CC05310G

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A visible-light photoactivatable di-nuclear Pt^IV triazolato azido complex†

Kezi Yao,^a Arnau Bertran,^a Alison Howarth,^a Jose M. Goicoechea,

^a Samuel M. Hare,^a Nicholas H. Rees,^a Mohammadali Foroozandeh,

^a Alice M. Bowen

^a and Nicola J. Farrer

*^a

Author affiliations

* Corresponding authors

^a Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK
E-mail: Nicola.Farrer@chem.ox.ac.uk
Tel: +44 (0)1865 285131

Abstract

A novel Pt^IV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a Pt^IV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5′-guanosine monophosphate (5′-GMP) produced both Pt^IV and Pt^II 5′-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals – particularly hydroxyl radicals – was significantly reduced in the presence of 5′-GMP.

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Article information

DOI: https://doi.org/10.1039/C9CC05310G
Article type: Communication
Submitted: 10 Jul 2019
Accepted: 30 Jul 2019
First published: 02 Sep 2019
This article is Open Access

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Chem. Commun., 2019,55, 11287-11290

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A visible-light photoactivatable di-nuclear Pt^IV triazolato azido complex

K. Yao, A. Bertran, A. Howarth, J. M. Goicoechea, S. M. Hare, N. H. Rees, M. Foroozandeh, A. M. Bowen and N. J. Farrer, Chem. Commun., 2019, 55, 11287 DOI: 10.1039/C9CC05310G

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