Issue 9, 2019
From the journal:

Soft Matter

Enantioselective cytotoxicity of chiral polymer vesicles with linear and hyperbranched structures†

Funing Liu,‡a   Hongli Zhang,‡a   Junjie Cheng,a   Jingang Hu,a   Chenlu He,a   Qijin Zhanga  and  Gang Zou ORCID logo *a  

* Corresponding authors

a CAS Key laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, iChEM, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: gangzou@ustc.edu.cn

Abstract

Herein, we study the enantioselective cytotoxicity of vesicles self-assembled by optically active linear polymers (LNPs) and hyperbranched polymers (HBPs). Compared to HBP vesicles, LNP vesicles exhibit properties such as a higher surface charge density and more violent interaction with simulated biomembranes which results in larger cytotoxicity against HeLa cells. Specifically, racemic-LNP vesicles exhibit the largest cytotoxicity of all. More interestingly, there is no significant enantioselective dependence of HBP vesicles on the abovementioned properties. Overall, we proved that the cytotoxicity of vesicles is deeply related to chirality and topological-structures. This research is of great fundamental value for the design of novel bio-interface materials.

Graphical abstract: Enantioselective cytotoxicity of chiral polymer vesicles with linear and hyperbranched structures

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Article information

DOI
https://doi.org/10.1039/C8SM02390E
Article type
Paper
Submitted
24 Nov 2018
Accepted
26 Jan 2019
First published
28 Jan 2019

Soft Matter, 2019,15, 2051-2056

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Enantioselective cytotoxicity of chiral polymer vesicles with linear and hyperbranched structures

F. Liu, H. Zhang, J. Cheng, J. Hu, C. He, Q. Zhang and G. Zou, Soft Matter, 2019, 15, 2051 DOI: 10.1039/C8SM02390E

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