Issue 13, 2019, Issue in Progress
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RSC Advances

Ochrasperfloroid, an ochratoxin–ergosteroid heterodimer with inhibition of IL-6 and NO production from Aspergillus flocculosus 16D-1†

Bin-Bin Gu,a   Fu-Rong Jiao,a   Wei Wu,a   Lei Liu,a   Wei-Hua Jiao, ORCID logo a   Fan Sun,a   Shu-Ping Wang,a   Fan Yanga  and  Hou-Wen Lin ORCID logo *a  

* Corresponding authors

a Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
E-mail: franklin67@126.com

Abstract

A novel ochratoxin–ergosteroid heterodimer, ochrasperfloroid (1), together with a known mycotoxin, ochratoxin A (2), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1. The structure of 1 was determined on the basis of 1D/2D NMR, HRESIMS/MS, and LC-UV/MS analysis of its alkaline hydrolyzates, quantum-chemical 13C NMR calculation, and comparison with literature data. Of note, the ergosteroid embedded in 1 is also a new structure. Ochrasperfloroid (1) showed potent inhibitory activity towards IL-6 production in lipopolysaccharide (LPS)-induced THP-1 cell line, with an IC50 value of 2.02 μM, and NO production in LPS-activated RAW264.7 macrophages, with an IC50 value of 1.11 μM.

Graphical abstract: Ochrasperfloroid, an ochratoxin–ergosteroid heterodimer with inhibition of IL-6 and NO production from Aspergillus flocculosus 16D-1

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Article information

DOI
https://doi.org/10.1039/C8RA10539A
Article type
Paper
Submitted
24 Dec 2018
Accepted
18 Feb 2019
First published
04 Mar 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 7251-7256

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Ochrasperfloroid, an ochratoxin–ergosteroid heterodimer with inhibition of IL-6 and NO production from Aspergillus flocculosus 16D-1

B. Gu, F. Jiao, W. Wu, L. Liu, W. Jiao, F. Sun, S. Wang, F. Yang and H. Lin, RSC Adv., 2019, 9, 7251 DOI: 10.1039/C8RA10539A

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