Issue 21, 2019

A reversible decomposition approach for the formation of injectable, excipient-free, self-assembling nanocrystals

Abstract

We have formulated 7-ethyl-10-hydroxy camptothecin (SN38) nanocrystals using a novel combination of reversible reactions and pharmaceutical technology. The nanocrystals are taken up more efficiently by cells and accumulate more in tumors than the commercially available camptothecin compound irinotecan (CPT-11), leading to superior anti-tumor efficacy in vitro and in vivo.

Graphical abstract: A reversible decomposition approach for the formation of injectable, excipient-free, self-assembling nanocrystals

Supplementary files

Article information

Article type
Communication
Submitted
24 Dec 2018
Accepted
19 Feb 2019
First published
19 Feb 2019

Chem. Commun., 2019,55, 3144-3147

A reversible decomposition approach for the formation of injectable, excipient-free, self-assembling nanocrystals

Q. Yang, T. Tan, J. Zhao, C. Zhou, C. Guo, Z. Wan, X. Song and T. Gong, Chem. Commun., 2019, 55, 3144 DOI: 10.1039/C8CC10191D

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