SCHEDULED MAINTENANCE
New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells†
Francisco J.
Ballester, 
‡a
Enrique
Ortega,
‡a
Hana
Kostrhunova,
c
Viktor
Brabec,
c
Fernando
Domínguez,
*b
M. Dolores
Santana
*a
and
José
Ruiz
*a
‡a
Enrique
Ortega,
‡a
Hana
Kostrhunova,
c
Viktor
Brabec,
c
Fernando
Domínguez,
*b
M. Dolores
Santana
*a
and
José
Ruiz
*a
Abstract
Half-sandwich ruthenium(II) complexes [(η6-p-cymene)Ru(C^N)-(X)]0/+ (X = Cl, py or 4-NMe2-py) containing a cyclometalated 2-ppy or 1-ppz with a non-coordinated CHO group as a handle for further functionalization have been synthesized to achieve selective cytotoxicity to cancer cells, the more potent compounds acting as proteosynthesis inhibitors; this is a new mode of action for half-sandwich metal complexes.
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