Issue 16, 2018
From the journal:

Chemical Communications

Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy†

Yang Li,ab   Tianyi Kang,b   Yujiao Wu,b   Yuwen Chen,b   Jiao Zhua  and  Maling Gou*ab  

* Corresponding authors

a West China Medical School of Si Chuan University, Chengdu, China
E-mail: gpumaling@scu.edu.cn

b State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China

Abstract

We report that carbonate esters could turn hydrophobic camptothecin (CPT)-unsaturated fatty acid prodrugs into nanoaggregates in aqueous solution. The active CPT could be rapidly released once triggered by a reductive stimulus when a carbonate ester was combined with a disulfide bond, resulting in a potent in vivo antitumor activity.

Graphical abstract: Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy

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Article information

DOI
https://doi.org/10.1039/C8CC00639C
Article type
Communication
Submitted
25 Jan 2018
Accepted
29 Jan 2018
First published
29 Jan 2018

Chem. Commun., 2018,54, 1996-1999

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Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy

Y. Li, T. Kang, Y. Wu, Y. Chen, J. Zhu and M. Gou, Chem. Commun., 2018, 54, 1996 DOI: 10.1039/C8CC00639C

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