Issue 11, 2018
From the journal:

Biomaterials Science

Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides†

Hamilton Kakwere, ORCID logo ab   Elizabeth S. Ingham,a   Riley Allen,a   Lisa M. Mahakian,a   Sarah M. Tam,a   Hua Zhang, ORCID logo ab   Matthew T. Silvestrini,a   Jamal S. Lewis ORCID logo a  and  Katherine W. Ferrara ORCID logo *b  

* Corresponding authors

a Department of Biomedical Engineering, University of California (Davis), Davis, CA 95616, USA

b Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, CA 94305, USA
E-mail: kwferrara@ucdavis.edu, kwferrar@stanford.edu

Abstract

Unimicellar hyperstar macromolecular chimeras displaying multiple melanoma peptide antigens were prepared primarily via a combination of click chemistry and esterification reactions starting from a biodegradable hyperbranched polymer template. Solubilization of the hyperstars in aqueous solution afforded a multi-antigen unimicellar cancer nanovaccine of about 20 nm. The nanovaccine showed good biocompatibility and uptake by dendritic cells in vitro. An in vivo evaluation of the nanovaccine therapeutic efficacy against melanoma in mice implanted with B16OVA tumors revealed significantly greater T-cell recruitment and improved survival rates for mice treated with nanovaccine and adjuvant compared to non-treated mice.

Graphical abstract: Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides

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Article information

DOI
https://doi.org/10.1039/C8BM00891D
Article type
Communication
Submitted
29 Jul 2018
Accepted
05 Sep 2018
First published
11 Sep 2018

Biomater. Sci., 2018,6, 2850-2858

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Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides

H. Kakwere, E. S. Ingham, R. Allen, L. M. Mahakian, S. M. Tam, H. Zhang, M. T. Silvestrini, J. S. Lewis and K. W. Ferrara, Biomater. Sci., 2018, 6, 2850 DOI: 10.1039/C8BM00891D

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