Issue 10, 2018
From the journal:

Biomaterials Science

Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation†

Heike Newland,a   Dimitri Eigel,a   Anne E. Rosser,b   Carsten Werner ORCID logo a  and  Ben Newland ORCID logo *ac  

* Corresponding authors

a Leibniz Institute of Polymer Research Dresden (IPF), Hohe Strasse 6, 01069 Dresden, Germany

b Brain Repair Group, School of Biosciences, Cardiff University, UK

c School of Pharmacy and Pharmaceutical Sciences, Cardiff University, UK
E-mail: newlandb@cardiff.ac.uk

Abstract

This study outlines the synthesis of microscale oxygen producing spheres, which, when used in conjunction with catalase, can raise the dissolved oxygen content of cell culture media for 16–20 hours. In conditions of oxygen and glucose deprivation, designed to mimic the graft environment in vivo, the spheres rescue SH-SY5Y cells and meschymal stem cells, showing that oxygen producing biomaterials may hold potential to improve the survival of cells post-transplantation.

Graphical abstract: Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

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Article information

DOI
https://doi.org/10.1039/C8BM00490K
Article type
Communication
Submitted
03 May 2018
Accepted
27 Jun 2018
First published
22 Aug 2018
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2018,6, 2571-2577

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Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

H. Newland, D. Eigel, A. E. Rosser, C. Werner and B. Newland, Biomater. Sci., 2018, 6, 2571 DOI: 10.1039/C8BM00490K

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