Gold nanoparticle based fluorescent oligonucleotide probes for imaging and therapy in living systems

Yanjing Yang; Shian Zhong; Kemin Wang; Jin Huang

doi:10.1039/C8AN02070A

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Gold nanoparticle based fluorescent oligonucleotide probes for imaging and therapy in living systems

Yanjing Yang,^ab Shian Zhong,

^a Kemin Wang

^b and Jin Huang

*^b

Author affiliations

* Corresponding authors

^a College of Chemistry and Chemical Engineering, Central South University, Changsha, PR China

^b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, P. R. China
E-mail: jinhuang@hnu.edu.cn

Abstract

Gold nanoparticles (AuNPs) with unique physical and chemical properties have become an integral part of research in nanoscience. In particular, the development of AuNP-based fluorescent oligonucleotide (AuFO) probes targeted at living systems through fluorescence are drawing increasing attention and have become a current hot topic in biomedical research. This review describes recent advances and developments in the use of AuFO probes from their preparation and features that allow the desired intracellular delivery to their applications in cellular imaging and drug delivery in living systems.

This article is part of the themed collection: Recent Review Articles

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Article information

DOI: https://doi.org/10.1039/C8AN02070A
Article type: Critical Review
Submitted: 27 Oct 2018
Accepted: 12 Dec 2018
First published: 13 Dec 2018

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Analyst, 2019,144, 1052-1072

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Gold nanoparticle based fluorescent oligonucleotide probes for imaging and therapy in living systems

Y. Yang, S. Zhong, K. Wang and J. Huang, Analyst, 2019, 144, 1052 DOI: 10.1039/C8AN02070A

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Gold nanoparticle based fluorescent oligonucleotide probes for imaging and therapy in living systems

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