Issue 59, 2017
From the journal:

RSC Advances

Phthalide derivatives from Ligusticum chuanxiong†

Xu Zhang,a   Bing Han,a   Zi-Ming Feng,a   Ya-Nan Yang, ORCID logo a   Jian-Shuang Jianga  and  Pei-Cheng Zhang*a  

* Corresponding authors

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, People′s Republic of China
E-mail: pczhang@imm.ac.cn

Abstract

Eleven new phthalide derivatives (1–11) have been isolated from the rhizome of Ligusticum chuanxiong. In particular, 1 and 2 contain a mercaptopropionic acid moiety in the phthalide derivatives. All the structures, including their absolute configurations, were determined by UV, IR, HRESIMS, 1D and 2D NMR spectroscopic measurements, and by a comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Results of a bioassay showed that compound 4 has a moderate neuroprotective activity on human neuroblastoma SH-SY5Y cell injury induced by H2O2 and oxygen glucose deprivation (OGD).

Graphical abstract: Phthalide derivatives from Ligusticum chuanxiong

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Article information

DOI
https://doi.org/10.1039/C7RA06813A
Article type
Paper
Submitted
19 Jun 2017
Accepted
25 Jul 2017
First published
31 Jul 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 37478-37486

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Phthalide derivatives from Ligusticum chuanxiong

X. Zhang, B. Han, Z. Feng, Y. Yang, J. Jiang and P. Zhang, RSC Adv., 2017, 7, 37478 DOI: 10.1039/C7RA06813A

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