Issue 33, 2017, Issue in Progress
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RSC Advances

Protective effects of a cocktail of lactic acid bacteria on microcystin-LR-induced hepatotoxicity and oxidative damage in BALB/c mice

Jichun Zhao,†a   Fengwei Tian,†ac   Qixiao Zhai,ac   Ruipeng Yu,a   Hao Zhang,ad   Zhennan Gu ORCID logo a  and  Wei Chen ORCID logo *abd  

* Corresponding authors

a State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China
E-mail: chenwei66@jiangnan.edu.cn
Fax: +86 510-85912155
Tel: +86 510-85912155

b Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology & Business University, Beijing 100048, P. R. China

c International Joint Research Laboratory for Probiotics, Jiangnan University, Wuxi 214122, P. R. China

d International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214122, P. R. China

Abstract

The aim of this study was to investigate the effects of mixed lactic acid bacteria (LAB) against microcystin-LR-exposed hepatotoxicity and oxidative stress in BALB/c mice. 20 LAB strains were randomly divided into three groups and the effects against microcystin-LR (MC-LR) toxicity investigated in vivo. The antioxidative abilities of the three LAB groups were also determined. The results showed that a cocktail of LAB 3 (CLAB3), including Lactobacillus johnsonii ATCC 33200, L. rhamnosus GG, Bifidobacterium adolescentis 1.1290 and B. bifidum CCFM 16, was able to significantly reverse the increased levels of serum ALT and AST, and liver tissue lesions by MC-LR. The alterations of hepatic malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activities in the CLAB3 were improved compared to the MC-LR group alone. Moreover, the free radical scavenging and reducing abilities of CLAB3 were higher than other groups. CLAB3 can significantly alleviate MC-LR-induced hepatic damage and improve its oxidative stress. Moreover, the protective effects of the CLAB3 groups are related to its outstanding antioxidative abilities in vitro. LAB can be a promising dietary strategy to prevent cyanobacteria contamination toxicity.

Graphical abstract: Protective effects of a cocktail of lactic acid bacteria on microcystin-LR-induced hepatotoxicity and oxidative damage in BALB/c mice

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Article information

DOI
https://doi.org/10.1039/C7RA03035E
Article type
Paper
Submitted
14 Mar 2017
Accepted
31 Mar 2017
First published
10 Apr 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 20480-20487

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Protective effects of a cocktail of lactic acid bacteria on microcystin-LR-induced hepatotoxicity and oxidative damage in BALB/c mice

J. Zhao, F. Tian, Q. Zhai, R. Yu, H. Zhang, Z. Gu and W. Chen, RSC Adv., 2017, 7, 20480 DOI: 10.1039/C7RA03035E

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