Issue 16, 2017
From the journal:

Dalton Transactions

Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae†

Nobuhiko Dojun,a   Yukari Sekine,a   Koichiro Ishimoriab  and  Takeshi Uchida ORCID logo *ab  

* Corresponding authors

a Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-8628, Japan

b Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan
E-mail: uchida@sci.hokudai.ac.jp

Abstract

HutZ is a heme-degrading enzyme. We found that the heme-degradation reaction by HutZ is inhibited by the iron chelators. Kinetic analysis of each heme-degradation step suggests that water molecules hydrogen bonded to Thr27 are involved in proton transfer to Fe(III)–OO−, and that this step is inhibited by iron chelators.

Graphical abstract: Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C7DT00121E
Article type
Communication
Submitted
12 Jan 2017
Accepted
17 Mar 2017
First published
17 Mar 2017

Dalton Trans., 2017,46, 5147-5150

Permissions

Request permissions

Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae

N. Dojun, Y. Sekine, K. Ishimori and T. Uchida, Dalton Trans., 2017, 46, 5147 DOI: 10.1039/C7DT00121E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements