Issue 32, 2017

Remote-control of the enantiomeric supramolecular recognition mediated by chiral azobenzenes bound to human serum albumin

Abstract

Three novel tyrosine-conjugated azobenzene molecules were designed and their ability to target a natural chiral host matrix (human serum albumin, HSA) was investigated. We found that the interplay between the spatial configuration of the chiral substituents and the change in local symmetry resulting from the photoisomerization process strongly affects the optical activity of the bound photochromes. In particular, the different signal amplification obtained upon binding of the photoswitches to the biopolymer enables obtaining a chirooptical system tunable over a wide range of wavelengths.

Graphical abstract: Remote-control of the enantiomeric supramolecular recognition mediated by chiral azobenzenes bound to human serum albumin

Supplementary files

Article information

Article type
Communication
Submitted
18 May 2017
Accepted
19 Jul 2017
First published
20 Jul 2017

Phys. Chem. Chem. Phys., 2017,19, 21272-21275

Remote-control of the enantiomeric supramolecular recognition mediated by chiral azobenzenes bound to human serum albumin

M. Deiana, Z. Pokladek, M. Dudek, S. G. Mucha, L. M. Mazur, K. Pawlik, P. Mlynarz, M. Samoc and K. Matczyszyn, Phys. Chem. Chem. Phys., 2017, 19, 21272 DOI: 10.1039/C7CP03336B

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