A single stranded fluorescent peptide probe for targeting collagen in connective tissues

Xiangdong Cai; Zhao Liu; Sha Zhao; Chen Song; Shouliang Dong; Jianxi Xiao

doi:10.1039/C7CC06056D

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A single stranded fluorescent peptide probe for targeting collagen in connective tissues†

Xiangdong Cai,^a Zhao Liu,^a Sha Zhao,^a Chen Song,^a Shouliang Dong

*^b and Jianxi Xiao

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
E-mail: xiaojx@lzu.edu.cn

^b Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China
E-mail: dongsl@lzu.edu.cn

Abstract

We herein report the construction of a novel single stranded fluorescent collagen mimetic peptide by introducing a bulky FAM dye in the central region rather than the N terminus. Without the need for any prior thermal or ultraviolet treatment, the peptide probe can be conveniently applied to specifically target collagen in connective tissues for fluorescence imaging.

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Article information

DOI: https://doi.org/10.1039/C7CC06056D
Article type: Communication
Submitted: 02 Aug 2017
Accepted: 09 Oct 2017
First published: 09 Oct 2017

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Chem. Commun., 2017,53, 11905-11908

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A single stranded fluorescent peptide probe for targeting collagen in connective tissues

X. Cai, Z. Liu, S. Zhao, C. Song, S. Dong and J. Xiao, Chem. Commun., 2017, 53, 11905 DOI: 10.1039/C7CC06056D

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Chemical Communications

A single stranded fluorescent peptide probe for targeting collagen in connective tissues†

Abstract

Supplementary files

Article information

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A single stranded fluorescent peptide probe for targeting collagen in connective tissues

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