The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the difference

Mariane Le Fur; Maryline Beyler; Enikő Molnár; Olivier Fougère; David Esteban-Gómez; Gyula Tircsó; Carlos Platas-Iglesias; Nicolas Lepareur; Olivier Rousseaux; Raphaël Tripier

doi:10.1039/C7CC05088G

The role of the capping bond effect on pyclen ^natY³⁺/⁹⁰Y³⁺ chelates: full control of the regiospecific N-functionalization makes the difference†

Mariane Le Fur,^a Maryline Beyler,^a Enikő Molnár,^b Olivier Fougère,^c David Esteban-Gómez,

^d Gyula Tircsó,

^b Carlos Platas-Iglesias,

^d Nicolas Lepareur,

^e Olivier Rousseaux*^b and Raphaël Tripier

*^a

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* Corresponding authors

^a Université de Bretagne Occidentale, UMR-CNRS 6521, UFR des Sciences et Techniques, 6 avenue Victor le Gorgeu, C.S. 93837, 29238 Brest Cedex 3, France
E-mail: raphael.tripier@univ-brest.fr

^b Department of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary

^c Guerbet Group, Centre de Recherche d'Aulnay-sous-Bois, BP 57400, 95943 Roissy CdG Cedex, France
E-mail: Olivier.Rousseaux@guerbet-group.com

^d Departamento de Química, Facultade de Ciencias & Centro de Investigaciones Científicas Avanzadas (CICA), Universidade da Coruña, 15071 A Coruña, Spain

^e Département de Médecine Nucléaire, Centre Eugène Marquis, INSERM U1241, Avenue de la Bataille Flandres, Dunkerque CS 44229, 35042 Rennes Cedex, France

Abstract

Thanks to a smart regiospecific N-functionalization, a pyclen based ligand bearing one picolinate and two acetate arms organized in a dissymmetric manner was synthesized for Y³⁺ complexation, and compared to its symmetric analogue. The nature of the capping bonds around the metal coordination environment has a dramatic effect on the properties of the chelate, the ^natY³⁺ and ⁹⁰Y³⁺ dissymmetric derivatives presenting enhanced thermodynamic stability and kinetic inertness.

Chemical Communications

The role of the capping bond effect on pyclen ^natY³⁺/⁹⁰Y³⁺ chelates: full control of the regiospecific N-functionalization makes the difference†

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The role of the capping bond effect on pyclen ^natY³⁺/⁹⁰Y³⁺ chelates: full control of the regiospecific N-functionalization makes the difference

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