Issue 3, 2017
From the journal:

Journal of Materials Chemistry B

Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles†

Jian-Hua Liu,‡a   Ulrike Wais,‡bc   Yan-Ming Zuo,a   Yu Xiang,a   Yan-Hong Wang,a   Alexander W. Jackson,c   Tao He*a  and  Haifei Zhang*b  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, China
E-mail: taohe@hfut.edu.cn

b Department of Chemistry, University of Liverpool, Liverpool, UK
E-mail: zhanghf@liv.ac.uk

c Institute of Chemical and Engineering Science, 1 Pesek Road, Jurong Island, Singapore

Abstract

Spherical unimolecular amphiphilic branched A-B block copolymer nanoparticles in methanol are fabricated via thermal annealing using the methanolic upper critical solution temperature (UCST) of the hydrophobic block segment. These polymer nanoparticles are then used to produce an aqueous poorly water-soluble drug nanoparticle suspension with a mass : drug ratio of 1 : 1 and 100% nanoparticle yield. The drug nanoparticles in the suspension are stabilized by multiple polymer nanoparticles.

Graphical abstract: Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6TB02940J
Article type
Communication
Submitted
10 Nov 2016
Accepted
05 Dec 2016
First published
05 Dec 2016

J. Mater. Chem. B, 2017,5, 423-427

Permissions

Request permissions

Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles

J. Liu, U. Wais, Y. Zuo, Y. Xiang, Y. Wang, A. W. Jackson, T. He and H. Zhang, J. Mater. Chem. B, 2017, 5, 423 DOI: 10.1039/C6TB02940J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements