Issue 42, 2017, Issue in Progress
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RSC Advances

The synergistic effect of type I collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: an in vitro and in vivo study

Haiyong Ao, ORCID logo †ab   Chucheng Lin,†c   Binen Nie,d   Shengbing Yang,d   Youtao Xie,b   Yizao Wan ORCID logo a  and  Xuebin Zheng*b  

* Corresponding authors

a School of Materials Science and Engineering, East China Jiaotong University, Nanchang, China 330013

b Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, China 200050
E-mail: xbzheng@mail.sic.ac.cn

c State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China 200050

d Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 200011

Abstract

Type I collagen and hyaluronic acid are both the main components of bone extracellular matrix, and play important roles in regulating a cell's behavior. In this study, the synergistic effects of type I collagen (Col) and hyaluronic acid (HA) on the biological properties of Col/HA-multilayer-modified titanium coatings were investigated. In vitro, the results of human mesenchymal stem cells culture indicated that Col/HA-multilayers-modified titanium coatings (TC-AA(C/H)6) could better improve a cell's adhesion, proliferation, and differentiation, compared with collagen-modified titanium coatings (TC-AAC) and hyaluronic acid-modified titanium coatings (TC-AAH). In vivo, the micro-CT images indicated that bone trabecula around TC-AA(C/H)6 were significantly more than with TC-AAC and TC-AAH. The fluorescence micrograph showed more active new bone formation around implants in TC-AA(C/H)6 group than in the TC-AAC and TC-AAH groups in the first month. Measurement of the bone-implant contact on the histological sections indicated there was significantly good osteointegration around TC-AA(C/H)6 implants than with the other two modified titanium coatings. All of these results demonstrated that there exists favorable synergistic effects of type I collagen and hyaluronic acid.

Graphical abstract: The synergistic effect of type I collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: an in vitro and in vivo study

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Article information

DOI
https://doi.org/10.1039/C6RA27364E
Article type
Paper
Submitted
26 Nov 2016
Accepted
23 Mar 2017
First published
15 May 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 25828-25837

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The synergistic effect of type I collagen and hyaluronic acid on the biological properties of Col/HA-multilayer-modified titanium coatings: an in vitro and in vivo study

H. Ao, C. Lin, B. Nie, S. Yang, Y. Xie, Y. Wan and X. Zheng, RSC Adv., 2017, 7, 25828 DOI: 10.1039/C6RA27364E

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