Issue 21, 2017, Issue in Progress
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RSC Advances

Physagulide Q suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells by regulating the ROS-JAK2/Src-STAT3 signaling pathway†

Yan-Wei Yang,a   Lei Yang,a   Chao Zhang,a   Cai-Yun Gao,a   Ting Maa  and  Ling-Yi Kong ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China
E-mail: cpu_lykong@126.com
Fax: +86-25-8327-1405
Tel: +86-25-8327-1405

Abstract

Physagulide Q (PQ), a new natural compound, was isolated from Physalis angulata L. in our laboratory. In this study, we observed that PQ suppressed cell proliferation and induced apoptosis in human hepatocellular carcinoma (HCC) cells. Signal transducer and activator of transcription 3 (STAT3) regulates the expression of various genes to control cell cycle progression and programmed cell death. PQ inhibited the phosphorylation of STAT3 on Tyr705 by suppressing the phosphorylation of its upstream protein kinases Janus-activated kinase 2 (JAK2) and Src. Furthermore, we found that PQ could induce production of reactive oxygen species (ROS) in human HCC cells. GSH, a ROS scavenger, abrogated the inhibitory effect of PQ on the JAK2/Src-STAT3 pathway in human HCC cells. These results suggested that PQ inhibited the STAT3 signaling pathway through the generation of ROS in human HCC cells.

Graphical abstract: Physagulide Q suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells by regulating the ROS-JAK2/Src-STAT3 signaling pathway

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Article information

DOI
https://doi.org/10.1039/C6RA25032G
Article type
Paper
Submitted
11 Oct 2016
Accepted
16 Feb 2017
First published
23 Feb 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 12793-12804

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Physagulide Q suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells by regulating the ROS-JAK2/Src-STAT3 signaling pathway

Y. Yang, L. Yang, C. Zhang, C. Gao, T. Ma and L. Kong, RSC Adv., 2017, 7, 12793 DOI: 10.1039/C6RA25032G

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