Two hydrazone copper(II) complexes: synthesis, crystal structure, cytotoxicity, and action mechanism

Kun Hu; Guimei Zhou; Zhong Zhang; Feiyan Li; Jingui Li; Fupei Liang

doi:10.1039/C6RA03478K

Two hydrazone copper(ii) complexes: synthesis, crystal structure, cytotoxicity, and action mechanism†

Kun Hu,^a Guimei Zhou,^a Zhong Zhang,^a Feiyan Li,^a Jingui Li^a and Fupei Liang*^ab

* Corresponding authors

^a State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin 541004, P. R. China
E-mail: fliangoffice@yahoo.com
Fax: +86-773-2120958

^b Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China

Abstract

Two copper(II) complexes with 8-quinolinecarbaldehyde o-vanilloylhydrazone (H-L1) and 8-quinolinecarbaldehyde salicylhydrazone (H-L2), [Cu(L1)NO₃] (1) and [Cu(L2)NO₃] (2), were synthesized and structurally characterized, respectively. Complexes 1 and 2 exhibited enhanced cytotoxicity against BEL-7402, Hep-G2, NCI-H460, MGC80-3, HeLa tumor cells compared with free ligands and copper(II) salt and slightly lower than that shown by cisplatin. And MGC80-3 cells are more sensitive to these two complexes relative to the normal liver cells. Cytotoxicity and action mechanism studies suggest 1 and 2 could cause MGC80-3 cell cycle arrest at G1 phase, which is induced by limiting the supply of cyclins D1 and E1 and inhibiting the activity of G1-phase-promoting cyclin–Cdk complexes. And complexes 1 and 2 led to cell apoptosis via the activation of Bcl-2 protein. Moreover, mitochondrial dysfunction was induced by both of complexes.

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DOI: https://doi.org/10.1039/C6RA03478K
Article type: Paper
Submitted: 06 Feb 2016
Accepted: 01 Apr 2016
First published: 05 Apr 2016

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RSC Adv., 2016,6, 36077-36084

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Two hydrazone copper(II) complexes: synthesis, crystal structure, cytotoxicity, and action mechanism

K. Hu, G. Zhou, Z. Zhang, F. Li, J. Li and F. Liang, RSC Adv., 2016, 6, 36077 DOI: 10.1039/C6RA03478K

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Two hydrazone copper(ii) complexes: synthesis, crystal structure, cytotoxicity, and action mechanism†

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Two hydrazone copper(II) complexes: synthesis, crystal structure, cytotoxicity, and action mechanism

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