Issue 33, 2016
From the journal:

Organic & Biomolecular Chemistry

One-pot construction of fused polycyclic heteroarenes involving 7-azaindoles and α,β-unsaturated ketones†

Shuai-Shuai Li,‡abc   Wei-Huan Li,‡a   Guo-Tai Zhang,a   Ying-Qi Xia,a   Chen-Fei Liu,a   Fu Su,a   Xiao-Mei Zhangb  and  Lin Dong*a  

* Corresponding authors

a Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

b Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China

c Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
E-mail: dongl@scu.edu.cn

Abstract

A novel one-pot synthesis of π-conjugated polycyclic compounds, which could undergo further facile transformation to form complex polycyclic heteroarene compounds, has been realized between 7-azaindoles and α,β-unsaturated ketones. This distinctive cascade process proceeds via a rhodium(III)-catalyzed alkylation/copper-catalyzed radical annulation–aromatization pathway.

Graphical abstract: One-pot construction of fused polycyclic heteroarenes involving 7-azaindoles and α,β-unsaturated ketones

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Article information

DOI
https://doi.org/10.1039/C6OB01437B
Article type
Communication
Submitted
05 Jul 2016
Accepted
01 Aug 2016
First published
01 Aug 2016

Org. Biomol. Chem., 2016,14, 7859-7863

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One-pot construction of fused polycyclic heteroarenes involving 7-azaindoles and α,β-unsaturated ketones

S. Li, W. Li, G. Zhang, Y. Xia, C. Liu, F. Su, X. Zhang and L. Dong, Org. Biomol. Chem., 2016, 14, 7859 DOI: 10.1039/C6OB01437B

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