Issue 11, 2017
From the journal:

Nanoscale

SERS- and luminescence-active Au–Au–UCNP trimers for attomolar detection of two cancer biomarkers†

Aihua Qu,‡ab   Xiaoling Wu,‡ab   Liguang Xu,ab   Liqiang Liu, ORCID logo *ab   Wei Ma,ab   Hua Kuang*ab  and  Chuanlai Xu ORCID logo ab  

* Corresponding authors

a State Key Lab of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China
E-mail: raxray@gmail.com, kuangh@jiangnan.edu.cn

b International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, People's Republic of China

Abstract

Alpha-fetoprotein (AFP) and mucoprotein1 (mucin-1) are two important disease biomarkers. Self-assembled gold nanoparticles (AuNPs) and upconversion nanoparticle (Au–Au–UCNP) trimers based on aptamers were developed for the ultrasensitive detection of AFP and mucin-1. The Au–Au–UCNP trimers produced ideal optical signals, with prominent Raman enhancement and fluorescence quenching effects. The surface-enhanced Raman scattering (SERS) intensity decreased in the presence of mucin-1 and the luminescence intensity increased in the presence of AFP. A limit of detection (LOD) of 4.1 aM and a wide linear range of 0.01–10 fM for the detection of mucin-1 were obtained with this SERS-encoded sensing system. Using the luminescence-encoded sensing system, a LOD of 0.059 aM and a wide linear range of 1–100 aM for the detection of AFP were obtained. These LODs are the lowest values reported so far. This approach has the advantage of detecting two disease biomarkers simultaneously.

Graphical abstract: SERS- and luminescence-active Au–Au–UCNP trimers for attomolar detection of two cancer biomarkers

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Article information

DOI
https://doi.org/10.1039/C6NR09114H
Article type
Paper
Submitted
25 Nov 2016
Accepted
17 Feb 2017
First published
20 Feb 2017

Nanoscale, 2017,9, 3865-3872

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SERS- and luminescence-active Au–Au–UCNP trimers for attomolar detection of two cancer biomarkers

A. Qu, X. Wu, L. Xu, L. Liu, W. Ma, H. Kuang and C. Xu, Nanoscale, 2017, 9, 3865 DOI: 10.1039/C6NR09114H

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