Issue 12, 2016
From the journal:

New Journal of Chemistry

Polyphenolic carbosilane dendrimers as anticancer agents against prostate cancer†

Gabriel Mencia,ab   Natalia Sanz del Olmo,ab   Laura Muñoz-Moreno,c   Marta Maroto-Diaz,ab   Rafael Gomez,ab   Paula Ortega,*ab   Ma José Carmena*c  and  F. Javier de la Mata*ab  

* Corresponding authors

a Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, Campus Universitario, Edificio de Farmacia, E-28871 Alcalá de Henares, Spain
E-mail: javier.delamata@uah.es
Fax: +34-91 8854683
Tel: +34-91 8854654

b Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain

c Departamento de Biología de Sistemas, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain

Abstract

Carbosilane dendrimers containing vanillin on the surface have been prepared with the purpose of combining the unique antioxidant and anticancer properties of polyphenols and dendrimers. These new compounds exhibit antioxidant potency as free-radical scavengers, as determined by DPPH and ABTS. Remarkably, all synthesized dendrimers exhibit improved antioxidant efficacy compared to vanillin. Anticancer activity has been studied against HeLa cervical and PC3 human prostate cancer cell lines. Proliferation, cell cycle, adhesion and migration in human prostate tumor cells have been studied. Data revealed a general trend indicating that polyphenolic dendrimers are more cytotoxic than their monopolyphenolic counterparts in both cancer cell lines.

Graphical abstract: Polyphenolic carbosilane dendrimers as anticancer agents against prostate cancer

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Article information

DOI
https://doi.org/10.1039/C6NJ02545E
Article type
Paper
Submitted
15 Aug 2016
Accepted
23 Oct 2016
First published
24 Oct 2016

New J. Chem., 2016,40, 10488-10497

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Polyphenolic carbosilane dendrimers as anticancer agents against prostate cancer

G. Mencia, N. S. del Olmo, L. Muñoz-Moreno, M. Maroto-Diaz, R. Gomez, P. Ortega, M. xmlns="http://www.rsc.org/schema/rscart38"> <. José Carmena and F. Javier de la Mata, New J. Chem., 2016, 40, 10488 DOI: 10.1039/C6NJ02545E

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