Vitamin B9 gels were found to be pH-switchable by adding triethylamine or acetic acid. Such recyclable gels can be used as novel co-crystallization media, resulting in four stoichiometric vitamin C co-crystals. Under highly supersaturated conditions, uniform microspheres of (VC)·(NA) with different particle sizes were obtained through a spherical crystallization process.
J. Wang, J. Bao, X. Fan, W. Dai and X. Mei, Chem. Commun., 2016, 52, 13452 DOI: 10.1039/C6CC07701C
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